Monday, July 15, 2024

Location: Rialto Center for the Arts

 

14:00

Registration

​

16:00

Opening

Giovanni Gadda ( Georgia State University)

Opening Lecture

16:15-17:00

Nigel Scrutton (University of Manchester)

Title: Flavoprotein photobiocatalysis and its industrialization:

can we realize the dream?

​

Session 1

 

Chair: Susan Miller  (University of California San Francisco)

17:00-17:30

Pimchai Chaiyen (Vidyasirimedhi Institute of Science and Technology)

Title: Diversified Flavin-Dependent Monooxygenases: From Mechanisms to Innovations

17:30-18:00

Bruce Palfey  (University of Michigan)

Title: Parsing potentials pinpoints proteins' power-passing, priming redox-reactants

18:00-18:30

Russ Hille (University of California, Riverside)

Title: Electron bifurcation as catalyzed by the crotonyl-CoA-dependent NADH:ferredoxin oxidoreductase EtfAB:bcd from Megasphaera elsdenii

18:30-22:00

Welcome Reception

 

 

 

Tuesday, July 16, 2024

Location: Student Center East, GSU.

Talks @ the Speaker’s Auditorium.

Lunch and Posters @ the Ballroom.

 

Session 2

 

Chair: David Ballou  (University of Michigan)

9:00-9:30

Robert Stanley (Temple University)

Title: iFADs - Dual fluorescent probes of flavoprotein redox

9:30-10:00

Maria A. Vanoni  (University of Milan)

Title: Structure-function studies of human MICAL1, the multidomain flavoenzyme participating in actin cytoskeleton dynamics

10:00-10:30

Anne-Frances Miller (University of Kentucky)

Title: From quantum to complex, the Coupling between protein and flavin that enables catalysis in electron transfer flavoproteins

10:30-11:00

Coffee/Tea Break

 

Session 3

 

Chair: David Ballou  (University of Michigan)

11:00-11:30

Todd Hyster (Princeton University)

Title: Emergent mechanisms in flavin photoenzymatic catalysis

11:30-12:00

Radek Cibulka  (University of Chemistry and Technology, Prague)

Title: Stable deazaflavin semiquinones: structure, generation, and application in photoredox catalysis

12:00-13:30

Lunch

 

Session 4

 

Chair: John Woodley  (Technical University of Denmark)

13:30-14:00

Donald Becker (University of Nebraska–Lincoln)

Title: Functional switching of a moonlighting enzyme in proline metabolism

14:00-14:30

Jack Tanner (University of Missouri)

Title: Structure-based discovery of inhibitors and inactivators of the flavoenzyme proline dehydrogenase

14:30-15:00

Coffee/Tea Break

 

Session 5: Young Investigator Talks I

 

Chair: John Woodley  (Technical University of Denmark)

15:00-15:20

Ariadna Pié Porta (Technical University of Denmark)

Title: Tube-in-tube reactor: a tool to measure oxygen affinity of enzymes

15:20-15:40

Joanna Quaye  (Georgia State University)

Title: Metal-triggered hydride transfer in D-2-hydroxyglutarate dehydrogenase from Pseudomonas aeruginosa

15:40-16:00

Ruihao Li  (Washington University in St Louis)

Title: Covalent mechanism-based Inhibitors of tetracycline destructases

16:00-19:00

Poster Session I + Drinks and snacks

 

Wednesday, July 17, 2024

Location: Student Center East, GSU.

Talks @ the Speaker’s Auditorium.

Lunch and Posters @ the Ballroom.

 

Session 6

 

Chair: Andrea Mattevi  (University of Pavia)

9:00-9:30

Hiroki Iida (Shimane University)

Title: Flavin-based organocatalysts and supramolecules for aerobic oxidations and chiral discrimination

9:30-10:00

Maria Barile  (University of Bari)

Title: Unravelling the structure-function relationships of the human bifunctional enzyme FAD synthase and its interaction with the “client” lysine demethylase 1

10:00-10:30

Loredano Pollegioni (Università degli studi dell'Insubria)

Title: Human D-aspartate oxidase: a key player in D-aspartate brain metabolism

10:30-11:00

Coffee/Tea Break

 

Session 7

 

Chair: Andrea Mattevi  (University of Pavia)

11:00-11:30

Milagros Medina (Universidad de Zaragoza)

Title: Dynamics and cooperativity in homodimeric flavoenzymes

11:30-12:00

Graham Moran  (Loyola University Chicago)

Title: A descriptive analysis of transient-state observations for thioredoxin glutathione reductase from Schistosoma mansoni

12:00-13:30

Lunch

 

Session 8

 

Chair: Colleen Byron  (Ripon College)

13:30-14:00

Claudia Binda (University of Pavia)

Title: Monoamine oxidases: neurons and beyond

14:00-14:30

Pablo Sobrado  (Virginia Tech)

Title: Flavin and protein motion control the binding and release of NADP(H) and the stereospecificity of hydride transfer in Class B flavin monooxygenases

14:30-15:00

Coffee/Tea Break

 

Session 9: Young Investigator Talks II

 

Chair: Colleen Byron  (Ripon College)

15:00-15:20

María González-Viegas (Freie Universität Berlin)

Title: Characterization of the two FADs of a bifurcating ETF via Infrared spectroelectrochemistry

15:20-15:40

Saniye G. Kaya  (University of Groningen)

Title: Flavin fixing: repurposing a flavin transferase to attach flavin cofactors to flavoproteins covalently

15:40-16:00

Carolin Mügge  (Ruhr University Bochum)

Title: A ferredoxin reductase – ferredoxin couple to drive CytP450-catalyzed alkane hydroxylation

16:00-19:00

Poster Session II + Drinks and snacks

 

 

Thursday, July 18, 2024

Location: Student Center East, GSU.

Talks @ the Speaker’s Auditorium.

Lunch @ the Ballroom.

 

Session 10

 

Chair: Marco Fraaije (University of Groningen)

9:00-9:30

Marten H. Vos (École Polytechnique)

Title: Ultrafast photoreactions in flavo-enzymes

9:30-10:00

Dirk Tischler  (Ruhr University Bochum)

Title: Revealing sequence-function relationships of 4-phenol oxidases to provide highly active biocatalysts

10:00-10:30

Elizabeth Trimmer (Grinnell College)

Title: Importance of leucine 277 for NADH binding in methylenetetrahydrofolate Reductase from Escherichia coli

10:30-11:00

Coffee/Tea Break

 

Session 11

 

Chair: Marco Fraaije (University of Groningen)

11:00-11:30

Jared Lewis (Indiana University)

Title: Identifying and engineering flavin dependent halogenases for selective catalysis

11:30-12:00

April Lukowski  (University of California San Diego)

Title: Enzymatic halogenation of terminal alkynes

12:00-13:30

Lunch

13:30-onward

Free Time 

 

Friday, July 19, 2024

Location: Student Center East, GSU.

Talks @ the Speaker’s Auditorium.

Lunch @ the Ballroom.

Banquet @ The Fernbank Museum

 

Session 12

 

Chair: Maria Antonietta Vanoni (University degli Studi di Milano)

9:00-9:30

Audrey Lamb (University of Texas at San Antonio)

Title: The fascinating enzymes that make riboflavin

9:30-10:00

Tadhg Begley  (Texas A&M University)

Title: Riboflavin catabolism: the destruction of an icon

10:00-10:30

Steven Rokita  (Johns Hopkins University)

Title: Controlling the redox chemistry of flavin is a cooperative activity in iodotyrosine deiodinase

10:30-11:00

Coffee/Tea Break

 

Session 13

 

Chair: Maria Antonietta Vanoni (University degli Studi di Milano)

11:00-11:30

Paul Fitzpatrick (The University of Texas Health Science Center)

Title: Oxidation of 6-hydroxynicotine by flavoproteins

11:30-12:00

José Manuel Martín García  (Institute of Physical Chemistry Blas Cabrera)

Title: Time-resolved serial crystallography to uncover the reaction mechanism and dynamics of the human NQO1 flavoenzyme

12:00-13:30

Lunch

13:30-14:30

Scientific Committee Meeting

 

17:45 
Meet at the Rialto Theater to board buses to the Fernbank Museum
18:30
Banquet Mixer and Access to the Museum's "A Walk Through Time in Georgia" Exhibit 
19:30-21:00
Conference Banquet
21:00-21:30
Closing Lecture
Dale Edmondson (Emory University)
Title: 50+ Years of flavin research: The importance of flavin meetings
21:45-22:00
Vince Massey Young Investigator Awards

22:30

Board buses to return to the Rialto Theater